Research Area:

Biophysics; Bioinformatics; Computational Biology; Prediction, Simulation, and Design of Membrane Proteins

Education:

Ph.D. Condensed Matter Physics, Shandong University, China, 2007.

B.Sc, Physics, Shandong University, China, 2002;　

Academic experiences:

Aug 2023-Now: Associate Professor with Tenure, Center for Quantitative Biology & Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, China.

2016-Jul 2023: Tenure Track Assistant Professor, Center for Quantitative Biology & Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, China.

2013-2015: Research Fellow (Newton fellowship and Marie Curie fellowship), University of Oxford, UK

2010-2012: Postdoc (Humboldt fellowship and Max-Planck fellowship), Max-Planck Institute for Biophysical Chemistry, Germany

2007-2009: Postdoc, University of Western Australia, Australia

Selected publications:

1. Han, Z.; Wang, L.; Song, C.* Improved Anisotropic Network Models for Membrane Protein Dynamics and Mechanosensitive Ion Channels. PRX Life 2026, 4, 013025.

2. Wang, L.#; Kang, K.#; Song, C.* ProtRAP-LM: Efficient Protein Relative Accessibility Prediction and Proteome-Wide Membrane Protein Screening. Genom. Proteom. Bioinform. 2026, qzag013.

3. Li, J.; Guo, H.; Song, C.* MemConverter: An Iterative Pipeline for Reprogramming Protein Localization in Membrane or Aqueous Solution. J. Chem. Theory Comput. 2026, 22, 2028-2042.

4. Li, J.#; Yang, C.#; Dong, R.; Juarez, J.; Wang, L.; Wettstein, M.; Wang, D.; Cao, C.; Lu, Y.*; Song, C.* Mechanism-Driven Screening of Membrane-Targeting and Pore-Forming Antimicrobial Peptides. Adv. Sci. 2025, e16470.

5. Dong, R.; Cao, Q.; Song, C.* Painting Peptides with Antimicrobial Potency Through Deep Reinforcement Learning. Adv. Sci. 2025, e06332.

6. Xue, L.; Yan, N.; Song, C.* Deciphering Ca²⁺ Permeation and Valence Selectivity in Ca_V1: Molecular Dynamics Simulations Reveal the Three-Ion Knock-On Mechanism. Proc. Natl. Acad. Sci. U.S.A. 2025, 122, e2424694122.

7. Yang, S.; Song, C.* Multiple-Basin Gō-Martini for Investigating Conformational Transitions and Environmental Interactions of Proteins. J. Chem. Theory Comput. 2025, 21, 5304–5321.

8. Wang, L.; Zhang, J.; Wang, D.; Song, C.* Membrane Contact Probability: An Essential and Predictive Character for the Structural and Functional Studies of Membrane Proteins. PLoS Comput. Biol. 2022, 18, e1009972.

9. Wang, Y.#; Guo, Y.#; Li, G.; Liu, C.; Wang, L.; Zhang, A.; Yan, Z.*; Song, C.* The Push-to-Open Mechanism of the Tethered Mechanosensitive Ion Channel NOMPC. eLife 2021, 10, e58388.

10. Zhang, A.; Yu, H.; Liu, C.; Song, C.* The Ca²⁺ Permeation Mechanism of the Ryanodine Receptor Revealed by a Multi-Site Ion Model. Nat. Commun. 2020, 11, 922.